Syhthesis and antitumor activity of alkoxylbiphenyl/curcumine conjugates / 国际药学研究杂志

Objective: To design and synthesize conjugates of alkoxylbiphenyl/C5-curcumine with antitumor activities. Methods: Bicyclol, acetone and benzaldehyde with various substituents were used as raw materials. The target compounds were obtained by oxidizing and Aldol condensation reaction. And their antitumor activities were evaluated by MTS assay in the parental sensitive K562 and drug-resistant K562/A02 cell lines. Results: Twelve alkoxylbiphenyl/C5-curcumine conjugates were prepared.